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Neuromodulation from electrical current towards myocardial metabolism - G.A.J. Jessurun

ISBN: 9789075092165
AUTEUR: G.A.J. Jessurun

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Neuromodulation from electrical current towards myocardial metabolism

...rds carbohydrate oxidation can improve pump func-tion and slow the progression of HF (23, 27, ... CV Physiology | Myocardial Metabolism ... ... myocardial metabolism and cardiac function often occur late in the development of HF. Methods of electrical neurostimulation. In 1965, Melzack and Wall proposed the 'gate control' theory, which provides a scientific base for electrical neuromodulation [].In brief, the authors postulated that stimulation of myelinated thick A-fibres modulate ('pain') signals processed in unmyelinated and relatively slow conducting C-fibres, via interneurons in the spinal cord. Myocardial Metabolism All cellular processes require ATP as a primary energy source. The hea ... Electrical neuromodulation improves myocardial perfusion ... ... . Myocardial Metabolism All cellular processes require ATP as a primary energy source. The heart requires ATP for the function of membrane transport systems (e.g., Na + /K + -ATPase ) as well as for sarcomere contraction and relaxation , which involve myosin ATPase and ATP-dependent transport of calcium by the sarcoplasmic reticulum. Myocardial energy metabolism in dilated cardiomyopathy R = − 0.70 P < 0.01 0.00 0.05 0.10 0.15 0.20 0.25 45 50 55 60 65 70 75 LV end diastolic diameter (mm) Free fatty acid uptake (µmol * min − 1 * g − 1) Control patients Dilated cardiomyopathy Figure 3. Myocardial fatty acid uptake plotted as a function of left ventricular end diastolic ... Electrical neurostimulation can be used to treat patients with refractory angina, it reduces angina and ischemia. Previous data have suggested that electrical neurostimulation may alleviate myocardial ischaemia through increased collateral perfusion. We investigated the effect of electrical neurostimulation on functional collateral perfusion, assessed by distal coronary pressure measurement ... Current views on neurostimulation in the treatment of cardiac ischemic syndromes: Published in: Pain, 66(2-3), 109 ... Reference(s) neurostimulation, angina pectoris, SPINAL-CORD STIMULATION, ELECTRICAL NERVE-STIMULATION, SEVERE ANGINA-PECTORIS, NORMAL CORONARY-ARTERIES, INTRACTABLE ANGINA, CHEST PAIN ... experienced one or more myocardial ... sinus rhythm and provoke VT/VF. The current understanding of LQT3 suggests that β-blockers are at least not harmful to patients with LQT3 and may be protective. Neuromodulation to treat cardiac arrhythmia Vagus nerve stimulation for VT/VF Vagus nerve stimulation (VNS) has been shown to suppress VT/VF in animal models of acute MI (Figure 1).46-48 Figure 1. Cardiac Muscle. (a) Cardiac muscle cells have myofibrils composed of myofilaments arranged in sarcomeres, T tubules to transmit the impulse from the sarcolemma to the interior of the cell, numerous mitochondria for energy, and intercalated discs that are found at the junction of different cardiac muscle cells. PDF | On Nov 5, 2018, Dmitrii Oleinikov and others published Myocardial Metabolism | Find, read and cite all the research you need on ResearchGate A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body; and monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective. An investigation into the 'carry over' effect of neurostimulation in the treatment of angina pectoris Article in International Journal of Clinical Practice 58(7):669-74 · August 2004 with 10 Reads Myocardial Metabolism. R. J. BING; From the Departments of Medicine and Physiology, The Medical College of Alabama, Birmingham, Ala. Current work is in neuromodulation using deep brain stimulation of the mesencephalic locomotor region tested in in combination with epidural stimulation after SCI. The other main lab focus is the study of multi-organ blood flow after SCI....